Solid phase synthesis of substituted aminosulfonyl ureas using a sulfonylcarbamate linker

被引：16

作者：

Fitzpatrick, LJ

Rivero, RA

机构：

[1] Drug Discovery, R.W. Johnson Pharmaceutical Res. I., Spring House, PA 19477, Welsh and McKean Roads

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(97)01795-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure for preparing substituted aminosulfonyl ureas on solid support is described. Chemoselective reaction of chlorosulfonyl isocyanate with the Wang resin followed by reaction with an amine provides resin-bound substituted aminosulfonylcarbamates. Heating of the resultant resin in THF with a second amine provides the desired substituted aminosulfonyl ureas in good yield and purity. (C) 1997 Elsevier Science Ltd.

引用

页码：7479 / 7482

页数：4

共 19 条

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