Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists

被引：37

作者：

Sugano, M

Sato, A

Saito, K

Takaishi, S

Matsushita, Y

Iijima, Y

机构：

[1] SANKYO CO LTD,BIOMED RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,PHARMACOL & MOL BIOL RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 26期

关键词：

D O I：

10.1021/jm950640q

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Phomactins, natural products isolated from the culture broth of marine fungus Phoma sp., were found to be active as PAF antagonists. This unique carbon skeleton led us to investigate the structure-activity relationship demonstrating that the lipophilicity at C-(7-8), acetoxy, (methoxycarbonyl)oxy, and S-isoxazolyloxy substitution at C-20, and 2-beta-OH configuration at C-2 are all required for the enhancement of inhibitor activity.

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页码：5281 / 5284

页数：4

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