The reaction of propiolate acetylides with nitrones. Synthesis of gamma-amino-alpha,beta-ethylenic acid derivatives

被引：45

作者：

Denis, JN ^{[1
]}

Tchertchian, S ^{[1
]}

Tomassini, A ^{[1
]}

Vallee, Y ^{[1
]}

机构：

[1] CNRS,LEDSS,F-38041 GRENOBLE,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(97)01210-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nitrones react with the lithium anions of ethyl and t-butyl propiolates to give acetylenic N-hydroxylamines. The reduction of these compounds with Zn in the presence of an acid leads to E and Z alpha,beta-ethylenic-gamma-aminoacids derivatives. The stereoselectivity of these reactions was studied. (C) 1997 Published by Elsevier Science Ltd.

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页码：5503 / 5506

页数：4

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