Synthesis of 4-(cyclic dialkylamino)-7-azaindoles by microwave heating of 4-halo-7-azaindoles and cyclic secondary amines

被引：16

作者：

Caldwell, John J. ^{[1
]}

Cheung, Kwal-Ming ^{[1
]}

Collins, Ian ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res UK Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 09期

关键词：

D O I：

10.1016/j.tetlet.2007.01.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic aromatic substitution of 4-chloro- and 4-fluoro-7-azaindoles with cyclic secondary amines tinder microwave heating gave a straightforward and rapid synthesis of 4-(cyclic dialkylamino)-7-azaindoles. 4-Fluoro-7-azaindoles showed a greater reactivity towards SNAr reactions tinder these conditions than 4-chloro-7-azaindole.

引用

页码：1527 / 1529

页数：3

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