Nonsense-mediated mRNA decay: target genes and functional diversification of effectors

被引：116

作者：

Rehwinkel, Jan

Raes, Jeroen

Izaurralde, Elisa

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] MPI Dev Biol, D-72076 Tubingen, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 11期

关键词：

D O I：

10.1016/j.tibs.2006.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent genome-wide identification of nonsensemediated mRNA decay (NMD) targets in yeast, fruitfly and human cells has provided insight into the biological functions and evolution of this mRNA quality control mechanism, revealing that NMD post-transcriptionally regulates an important fraction of the transcriptome. NMD targets are associated with a broad range of biological processes, but most of these targets are not encoded by orthologous genes across different species. Yeast and fruitfly NMD effectors regulate common targets in concert, but parallel pathways have evolved in humans, whereby NMD effectors have acquired additional functions. Thus, the phenotypic differences observed across species after inhibition of NMD are driven not only by the functional diversification of NMD effectors but also by changes in the repertoire of regulated genes.

引用

收藏

页码：639 / 646

页数：8

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