Air-Stable Secondary Phosphine Oxide as Preligand for Palladium-Catalyzed Intramolecular α-Arylations with Chloroarenes

被引：92

作者：

Ackermann, Lutz ^{[1
]}

Vicente, Ruben ^{[1
]}

Hofmann, Nora ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 19期

关键词：

CROSS-COUPLING REACTIONS; HETEROCYCLIC CARBENE LIGANDS; SIMPLE INDOLE ALKALOIDS; BOND-FORMING REACTIONS; C-C; ARYL CHLORIDES; RATE ACCELERATION; ACTIVATION; EFFICIENT; KETONES;

D O I：

10.1021/ol901597d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium catalyst derived from air-stable secondary phosphine oxide (1-Ad)(2)P(O)H enabled efficient intramolecular alpha-arylations of amides with aryl chlorides, which allowed for the synthesis of diversely substituted (aza)oxindoles.

引用

页码：4274 / 4276

页数：3

共 70 条

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