The platelet proteome

被引：178

作者：

Senzel, Lisa ^{[1
]}

Gnatenko, Dmitri V. ^{[2
]}

Bahou, Wadie F. ^{[2
]}

机构：

[1] Univ Hosp, Dept Pathol, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Div Hematol, Dept Med, Stony Brook, NY 11794 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2009年 / 16卷 / 05期

关键词：

mass spectrometry; platelets; proteomics; releasate; ACTIVATED PLATELETS; MASS-SPECTROMETRY; PROTEINS; REVEALS; STORAGE; PHOSPHORYLATION; IDENTIFICATION; RELEASATE; DISCOVERY; BIOMARKER;

D O I：

10.1097/MOH.0b013e32832e9dc6

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Purpose of review The proteome is the pool of proteins expressed at a given time and circumstance. The word 'proteomics' summarizes several technologies for visualization, quantitation and identification of these proteins. Recent advances in these techniques are helping to elucidate platelet processes which are relevant to bleeding and clotting disorders, transfusion medicine and regulation of angiogenesis. Recent findings Over 1100 platelet proteins have been identified using proteomic techniques. Various subproteomes have been characterized, including platelet releasates (the 'secretome'), alpha and dense granules, membrane and cytoskeletal proteins, platelet-derived microparticles, and the platelet 'phosphoproteome'. Proteomic data about platelets have become increasingly available in integrated databases. Summary Proteomic experiments in resting and activated platelets have identified novel signaling pathways and secreted proteins which may represent therapeutic targets, as well as potential cancer biomarkers.

引用

页码：329 / 333

页数：5

共 42 条

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