Neuronal calcium sensor proteins:: generating diversity in neuronal Ca2+ signalling

被引:424
作者
Burgoyne, Robert D. [1 ]
机构
[1] Univ Liverpool, Sch Biomed Sci, Physiol Lab, Liverpool L69 3BX, Merseyside, England
基金
英国惠康基金;
关键词
D O I
10.1038/nrn2093
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neuronal Ca2+ signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+ signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.
引用
收藏
页码:182 / 193
页数:12
相关论文
共 152 条
[21]   Dynamics of cyclic GMP synthesis in retinal rods [J].
Burns, ME ;
Mendez, A ;
Chen, J ;
Baylor, DA .
NEURON, 2002, 36 (01) :81-91
[22]   Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment [J].
Buxbaum, JD ;
Choi, EK ;
Luo, YX ;
Lilliehook, C ;
Crowley, AC ;
Merriam, DE ;
Wasco, W .
NATURE MEDICINE, 1998, 4 (10) :1177-1181
[23]   Contribution of N- and C-terminal channel domains to Kv channel interacting proteins in a mammalian cell line [J].
Callsen, B ;
Isbrandt, D ;
Sauter, K ;
Hartmann, LS ;
Pongs, O ;
Bähring, R .
JOURNAL OF PHYSIOLOGY-LONDON, 2005, 568 (02) :397-412
[24]   DREAM is a Ca2+-regulated transcriptional repressor [J].
Carrión, AM ;
Link, WA ;
Ledo, F ;
Mellström, B ;
Naranjo, JR .
NATURE, 1999, 398 (6722) :80-84
[25]   CA2+-DEPENDENT INTERACTION OF RECOVERIN WITH RHODOPSIN KINASE [J].
CHEN, CK ;
INGLESE, J ;
LEFKOWITZ, RJ ;
HURLEY, JB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (30) :18060-18066
[26]   DREAM is a critical transcriptional repressor for pain modulation [J].
Cheng, HYM ;
Pitcher, GM ;
Laviolette, SR ;
Whishaw, IQ ;
Tong, KI ;
Kockeritz, LK ;
Wada, T ;
Joza, NA ;
Crackower, M ;
Goncalves, J ;
Sarosi, I ;
Woodgett, JR ;
Oliveira-dos-Santos, AJ ;
Ikura, M ;
van der Kooy, D ;
Salter, MW ;
Penninger, JM .
CELL, 2002, 108 (01) :31-43
[27]  
Coukell B, 2004, DEV GROWTH DIFFER, V46, P449
[28]  
COX JA, 1994, J BIOL CHEM, V269, P32807
[29]   Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence [J].
Dahl, J. P. ;
Jepson, C. ;
Levenson, R. ;
Wileyto, E. P. ;
Patterson, F. ;
Berrettini, W. H. ;
Lerman, C. .
PHARMACOGENOMICS JOURNAL, 2006, 6 (03) :194-199
[30]   The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion [J].
Dai, Feihan F. ;
Zhang, Yi ;
Kang, Youhou ;
Wang, Qinghua ;
Gaisano, Herbert Y. ;
Braunewell, Karl-Heinz ;
Chan, Catherine B. ;
Wheeler, Michael B. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (31) :21942-21953