Virus trafficking - learning from single-virus tracking

被引：328

作者：

Brandenburg, Boerries

Zhuang, Xiaowei ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrmicro1615

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

What could be a better way to study virus trafficking than 'miniaturizing oneself' and 'taking a ride with the virus particle' on its journey into the cell? Single-virus tracking in living cells potentially provides us with the means to visualize the virus journey. This approach allows us to follow the fate of individual virus particles and monitor dynamic interactions between viruses and cellular structures, revealing previously unobservable infection steps. The entry, trafficking and egress mechanisms of various animal viruses have been elucidated using this method. The combination of single-virus trafficking with systems approaches and state-of-the-art imaging technologies should prove exciting in the future.

引用

收藏

页码：197 / 208

页数：12

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