Telomere architecture

被引：61

作者：

Rhodes, D ^{[1
]}

Fairall, L ^{[1
]}

Simonsson, T ^{[1
]}

Court, R ^{[1
]}

Chapman, L ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

EMBO REPORTS | 2002年 / 3卷 / 12期

关键词：

D O I：

10.1093/embo-reports/kvf246

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are protein-DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric proteins that bind to double and single-stranded telomeric DNA shows that, despite a lack of extensive amino-acid sequence conservation, telomeric DNA recognition occurs via conserved DNA-binding domains. Furthermore, telomeric proteins have multidomain structures and hence are conformationally flexible. A possibility is that telomeric proteins take up different conformations when bound to different partners, providing a simple mechanism for modulating telomere architecture.

引用

收藏

页码：1139 / 1145

页数：7

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