Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers

被引：254

作者：

Caldorera-Moore, Mary ^{[1
]}

Guimard, Nathalie ^{[1
]}

Shi, Li ^{[2
]}

Roy, Krishnendu ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[2] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA

来源：

EXPERT OPINION ON DRUG DELIVERY | 2010年 / 7卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

SEE VOL. 232; GENE DELIVERY; PLASMID DNA; CELLULAR INTERNALIZATION; FUSOGENIC LIPOSOMES; POLYMERIC MICELLES; PARTICLE-SIZE; TUMOR; PH; ULTRASOUND;

D O I：

10.1517/17425240903579971

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Areas covered in this review: How recent advances in fabrication technology allow synthesis of highly monodisperse, stimuli-responsive, drug-carrying nanoparticles of precise geometries is discussed. How particle properties, specifically shape and stimuli responsiveness, affect biodistribution, cellular uptake and drug release is also reviewed. What the reader will gain: The reader is introduced to recent developments in intelligent drug nanocarriers and new nanofabrication approaches that can be combined with disease-responsive biomaterials. This will provide insight into the importance of controlling particle geometry and incorporating stimuli-responsive materials into drug delivery. Take home message: The integration of responsive biomaterials into shape-specific nanocarriers is one of the most promising avenues towards the development of next generation, advanced drug delivery systems.

引用

页码：479 / 495

页数：17

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