Inhibitory effect of Panax notoginseng on nitric oxide synthase, cyclo-oxygenase-2 and neutrophil functions

被引:16
作者
Jin, Un-Ho
Park, Soon-Gi
Suh, Seok-Jong
Kim, June-Ki
Kim, Dong-Soo
Moon, Sung-Kwon
Lee, Young-Choon
Park, Won-Hwan
Kim, Cheorl-Ho
机构
[1] Sungkyunkwan Univ, Dept Biol Sci, Suwon 440746, South Korea
[2] Dongguk Univ, Cardiovasc Med Res Ctr, Kyungju 780714, Kyungbuk, South Korea
[3] Kyungsung Univ, Dept Food Sci & Technol, Pusan, South Korea
[4] Chungju Natl Univ, Dept Food & Biotechnol, Chungju, Chungbuk, South Korea
[5] Dong A Univ, Dept Biotechnol, Pusan 604701, South Korea
关键词
Panax notoginseng Buck FH Chen. (Arialiaceae); nitric oxide; macrophage; neutrophil; carrageenan paw oedema;
D O I
10.1002/ptr.2018
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A water extract of Panax notoginseng Buck F.H. Chen. (Arialiaceae) root (PN) is being used as a therapeutic agent to stop haemorrhages and as a tonic to promote health in Korean and Chinese medicine. The pharmacokinetic profiles of PN have not been accurately investigated. The preliminary aim was to elucidate the pharmacokinetic features of PN. First, the prevention of neutrophil functions was assessed. PN inhibited neutrophil functions, including degranulation, superoxide generation and leukotriene B4 production, without any effect on 5-lipoxygenase activity. PN reduced nitric oxide (NO) and prostaglandin (PG)E2 production in mouse peritoneal macrophages stimulated with lipopolysaccharide (LPS) while no influence on the activity of inducible NO synthase (iNOS), cyclo-oxygenase-2 (COX-2) or cyclo-oxygenase-1 (COX-1) was observed. PN significantly reduced mouse paw oedema induced by carrageenan. The results indicate that PN exerts anti-inflammatory effects related to the inhibition of neutrophil functions and NO and PGE2 production, which could be due to a decreased expression of iNOS and COX-2. Copyright 0 2006 John Wiley & Sons, Ltd.
引用
收藏
页码:142 / 148
页数:7
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