Transcriptional homeostatic control of membrane lipid composition

被引：35

作者：

Thewke, D ^{[1
]}

Kramer, M ^{[1
]}

Sinensky, MS ^{[1
]}

机构：

[1] E Tennessee State Univ, James H Quillen Coll Med, Dept Biochem & Mol Biol, Johnson City, TN 37614 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 273卷 / 01期

关键词：

membrane fluidity; SREBP; oleate;

D O I：

10.1006/bbrc.2000.2826

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma membranes have a structural property, commonly referred to as membrane fluidity, that is compositionally regulated. The two main features of plasma membrane lipid composition that determine membrane fluidity are the ratio of cholesterol to phospholipids and the ratio of saturated to unsaturated fatty acids that are incorporated into the phospholipids. These ratios are determined, at least in part, by regulation of membrane lipid biosynthesis-particularly that of cholesterol and oleate. It now appears that cholesterol and oleate biosynthesis are feedback regulated by a common transcriptional mechanism which is governed by the maturation of the SREBP transcription factors. In this article, we briefly review our current understanding of transcriptional regulation of plasma membrane lipid biosynthesis by sterols and oleate. We also discuss studies related to the mechanism by which the physical state of membrane lipids signals the transcriptional regulatory machinery to control the rates of synthesis of these structural components of the lipid bilayer. (C) 2000 Academic Press.

引用

页码：1 / 4

页数：4

共 50 条

[1] STEROL REGULATION OF FATTY-ACID SYNTHASE PROMOTER - COORDINATE FEEDBACK-REGULATION OF 2 MAJOR LIPID PATHWAYS [J].

BENNETT, MK ;

LOPEZ, JM ;

SANCHEZ, HB ;

OSBORNE, TF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) :25578-25583

[2] Functions of lipid rafts in biological membranes [J].

Brown, DA ;

London, E .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :111-136

[3] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [J].

Brown, MS ;

Goldstein, JL .

CELL, 1997, 89 (03) :331-340

[4] ISOLATION AND CHARACTERIZATION OF AN UNSATURATED FATTY ACID REQUIRING MUTANT OF CULTURED MAMMALIAN-CELLS [J].

CHANG, TY ;

VAGELOS, PR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (01) :24-28

[5] Chinese hamster ovary cell mutants affecting cholesterol metabolism [J].

Chang, TY ;

Hasan, MT ;

Chin, J ;

Chang, CCY ;

Spillane, DM ;

Chen, J .

CURRENT OPINION IN LIPIDOLOGY, 1997, 8 (02) :65-71

[6] Role of multidrug resistance P-glycoproteins in cholesterol esterification [J].

Debry, P ;

Nash, EA ;

Neklason, DW ;

Metherall, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (02) :1026-1031

[7] P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries [J].

Demeule, M ;

Jodoin, J ;

Gingras, D ;

Béliveau, R .

FEBS LETTERS, 2000, 466 (2-3) :219-224

[8] Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway [J].

Edwards, PA ;

Ericsson, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :157-185

[9] LOSS OF TRANSCRIPTIONAL ACTIVATION OF 3 STEROL-REGULATED GENES IN MUTANT HAMSTER-CELLS [J].

EVANS, MJ ;

METHERALL, JE .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (09) :5175-5185

[10]

Fielding CJ, 1997, J LIPID RES, V38, P1503

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