Contribution of Transcranial Magnetic Stimulation to the Understanding of Functional Recovery Mechanisms After Stroke

被引:87
作者
Dimyan, Michael A. [1 ]
Cohen, Leonardo G. [1 ]
机构
[1] NINDS, Human Cort Physiol & Stroke Neurorehabil Sect, NIH, Bethesda, MD 20892 USA
关键词
stroke; TMS; tDCS; motor cortex; rehabilitation; MOTOR CORTEX EXCITABILITY; INDUCED MOVEMENT THERAPY; TIME FOLLOWING STROKE; UNAFFECTED HEMISPHERE; INTERHEMISPHERIC INHIBITION; CORTICOSPINAL EXCITABILITY; CORTICAL EXCITABILITY; SOMATOSENSORY STIMULATION; NEUROTROPHIC FACTOR; BRAIN-STIMULATION;
D O I
10.1177/1545968309345270
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Motor impairments are a major cause of morbidity and disability after stroke. This article reviews evidence obtained using transcranial magnetic stimulation (TMS) that provides new insight into mechanisms of impaired motor control and disability. They briefly discuss the use of TMS in the diagnosis, prognosis, and therapy of poststroke motor disability. Particular emphasis is placed on TMS as a tool to explore mechanisms of neuroplasticity during spontaneous and treatment-induced recovery of motor function to develop more rational and clinically useful interventions for stroke rehabilitation.
引用
收藏
页码:125 / 135
页数:11
相关论文
共 162 条
[21]   Somatosensory stimulation enhances the effects of training functional hand tasks in patients with chronic stroke [J].
Celnik, Pablo ;
Hummel, Friedhelm ;
Harris-Love, Michelle ;
Wolk, Rebecca ;
Cohen, Leonardo G. .
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2007, 88 (11) :1369-1376
[22]   The Future of Restorative Neurosciences in Stroke: Driving the Translational Research Pipeline From Basic Science to Rehabilitation of People After Stroke [J].
Cheeran, Binith ;
Cohen, Leonardo ;
Dobkin, Bruce ;
Ford, Gary ;
Greenwood, Richard ;
Howard, David ;
Husain, Masud ;
Macleod, Malcolm ;
Nudo, Randolph ;
Rothwell, John ;
Rudd, Anthony ;
Teo, James ;
Ward, Nicholas ;
Wolf, Steven .
NEUROREHABILITATION AND NEURAL REPAIR, 2009, 23 (02) :97-107
[23]   A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS [J].
Cheeran, Binith ;
Talelli, Penelope ;
Mori, Francesco ;
Koch, Giacomo ;
Suppa, Antonio ;
Edwards, Mark ;
Houlden, Henry ;
Bhatia, Kailash ;
Greenwood, Richard ;
Rothwell, John C. .
JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (23) :5717-5725
[24]   Effects of phenytoin on cortical excitability in humans [J].
Chen, R ;
Samii, A ;
Canos, M ;
Wassermann, EM ;
Hallett, M .
NEUROLOGY, 1997, 49 (03) :881-883
[25]   Interactions between inhibitory and excitatory circuits in the human motor cortex [J].
Chen, R .
EXPERIMENTAL BRAIN RESEARCH, 2004, 154 (01) :1-10
[26]   Organization of ipsilateral excitatory and inhibitory pathways in the human motor cortex [J].
Chen, R ;
Yung, D ;
Li, JY .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (03) :1256-1264
[27]   Interhemispheric asymmetries of motor cortex excitability in the postacute stroke stage - A paired-pulse transcranial magnetic stimulation study [J].
Cicinelli, P ;
Pasqualetti, P ;
Zaccagnini, M ;
Traversa, R ;
Oliveri, M ;
Rossini, PM .
STROKE, 2003, 34 (11) :2653-2658
[28]   Post-stroke reorganization of brain motor output to the hand: a 2-4 month follow-up with focal magnetic transcranial stimulation [J].
Cicinelli, P ;
Traversa, R ;
Rossini, PM .
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1997, 105 (06) :438-450
[29]   Suprathreshold 0.3 Hz repetitive TMS prolongs the cortical silent period: potential implications for therapeutic trials in epilepsy [J].
Cincotta, M ;
Borgheresi, A ;
Gambetti, C ;
Balestrieri, F ;
Rossi, L ;
Zaccara, G ;
Ulivelli, M ;
Rossi, S ;
Civardi, C ;
Cantello, R .
CLINICAL NEUROPHYSIOLOGY, 2003, 114 (10) :1827-1833
[30]   Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans [J].
Civardi, C ;
Cantello, R ;
Asselman, P ;
Rothwell, JC .
NEUROIMAGE, 2001, 14 (06) :1444-1453