Transcription Dynamics

被引：395

作者：

Hager, Gordon L. ^{[1
]}

McNally, James G. ^{[1
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR CELL | 2009年 / 35卷 / 06期

关键词：

RNA-POLYMERASE-II; EMBRYONIC STEM-CELLS; ESTROGEN-RECEPTOR-ALPHA; BETA-GLOBIN LOCUS; TATA-BINDING PROTEIN; INTERACTIONS IN-VIVO; GLUCOCORTICOID-RECEPTOR; LIVING CELLS; GENE-EXPRESSION; ANDROGEN RECEPTOR;

D O I：

10.1016/j.molcel.2009.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

All aspects of transcription and its regulation involve dynamic events. The basal transcription machinery and regulatory components are dynamically recruited to their target genes, and dynamic interactions of transcription factors with chromatin-and with each other-play a key role in RNA polymerase assembly, initiation, and elongation. These short-term binding dynamics of transcription factors are superimposed by long-term cyclical behavior of chromatin opening and transcription factor-binding events. Its dynamic nature is not only a fundamental property of the transcription machinery, but it is emerging as an important modulator of physiological processes, particularly in differentiation and development.

引用

页码：741 / 753

页数：13

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