Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients

被引:48
作者
Campbell, Andrew [2 ]
Minniti, Caterina P. [3 ,4 ]
Nouraie, Mehdi
Arteta, Manuel [2 ]
Rana, Sohail
Onyekwere, Onyinye
Sable, Craig [5 ]
Ensing, Gregory [2 ]
Dham, Niti [5 ]
Luchtman-Jones, Lori [5 ]
Kato, Gregory J. [3 ,4 ]
Gladwin, Mark T. [6 ]
Castro, Oswaldo L.
Gordeuk, Victor R. [1 ]
机构
[1] Howard Univ, Ctr Sickle Cell Dis, Washington, DC 20001 USA
[2] Univ Michigan, Ann Arbor, MI 48109 USA
[3] NHLBI, Bethesda, MD 20892 USA
[4] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA
[5] Childrens Natl Med Ctr, Washington, DC 20010 USA
[6] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA
关键词
sickle cell disease; paediatric; oxygen saturation; six-minute walk; pulmonary hypertension; REGURGITANT JET VELOCITY; PULSE OXIMETRY; PULMONARY-HYPERTENSION; CHEST SYNDROME; LUNG-FUNCTION; CHILDREN; STANDARDIZATION; DESATURATION; HYPOXEMIA; HEMOLYSIS;
D O I
10.1111/j.1365-2141.2009.07854.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P>Low steady state haemoglobin oxygen saturation in patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3-20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation < 99% (P < 0 center dot 0001), 9% of patients versus no controls had saturation < 95% (P = 0 center dot 008) and 8% of patients versus no controls had exercise-induced reduction in saturation >= 3%. Decreasing haemoglobin concentration (P < 0 center dot 001) and increasing haemolysis (P < 0 center dot 003) but not pulmonary function tests were independent predictors of both lower steady-state saturation and exercise-induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady-state oxygen saturation or exercise-induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation (P = 0 center dot 003) and with greater decline in oxygen saturation during the six-minute walk (P = 0 center dot 022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease.
引用
收藏
页码:352 / 359
页数:8
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