Development of a manufacturing route to 1-hydroxy-4-(3-pyridyl)butan-2-one using heck methodology

被引：6

作者：

Ainge, D ^{[1
]}

Vaz, LM ^{[1
]}

机构：

[1] AstraZeneca, Proc Res & Dev Dept, Loughborough LE11 5RH, Leics, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2002年 / 6卷 / 06期

关键词：

D O I：

10.1021/op0255736

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The optimisation and scale-up of a manufacturing route to a key intermediate, 1-hydroxy-4-(3-pyridyl)butan-2-one, utilising the Heck coupling of 3-bromopyridine and 3-butene-1,2-diol, is described.

引用

页码：811 / 813

页数：3

共 9 条

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[8] 2-I
[9] A highly active phosphine-free catalyst system for Heck reactions of aryl bromides
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