Changes of brain activity in the aged SAMP mouse

被引：20

作者：

Zhang, Lihong

Wolff, Lucille T.

Antonio, Gregory E.

Yeung, David K. W.

Zhang, Aiqun

Wu, Yan

Yew, David T. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China

[2] Hebei Med Univ, Hosp 1, Dept Neurol, Shijiazhuang, Peoples R China

[3] Chinese Univ Hong Kong, Dept Diagnost Radiol & Organ Imaging, Shatin, Hong Kong, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Beijing 100853, Peoples R China

[5] Capital Univ Med Sci, Dept Anat, Beijing 100054, Peoples R China

来源：

BIOGERONTOLOGY | 2007年 / 8卷 / 02期

关键词：

aging; fMRI; functional compensation; SAMP mice; senescence;

D O I：

10.1007/s10522-006-9035-9

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for functional and molecular changes in their brains, specifically in the hippocampus and somatosensory cortex. There was no statistically significant increase in the apoptosis indicators as revealed by Western Blotting for BAD and TUNEL experiments. However, the functional magnetic resonance imaging showed an increase in the area of BOLD images from the 3-month old to the 10-months old SAMP mice upon the application of tail stimulus. These results demonstrated a lack of neuronal deaths but an increase in the activated brain area with age.

引用

页码：81 / 88

页数：8

共 44 条

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