CRL4s: the CUL4-RING E3 ubiquitin ligases

被引：326

作者：

Jackson, Sarah ^{[1
]}

Xiong, Yue ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 11期

关键词：

DNA-BINDING PROTEIN; PIGMENTOSUM GROUP-E; VIRUS X-PROTEIN; LINKED MENTAL-RETARDATION; PARAMYXOVIRUS-V PROTEIN; CELL NUCLEAR ANTIGEN; E GENE-PRODUCT; DAMAGED DNA; SCHIZOSACCHAROMYCES-POMBE; S-PHASE;

D O I：

10.1016/j.tibs.2009.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3 ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three founding cullins conserved from yeast to humans, uses a large beta-propeller protein, DDB1, as a linker to interact with a subset of WD40 proteins that serve as substrate receptors, forming as many as 90 E3 complexes in mammals. Many CRL4 complexes are involved in chromatin regulation and are frequently hijacked by different viruses.

引用

收藏

页码：562 / 570

页数：9

相关论文

共 100 条

[61] A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression [J].

Michel, JJ ;

McCarville, JF ;

Xiong, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (25) :22828-22837

[62] PCNA, the maestro of the replication fork [J].

Moldovan, George-Lucian ;

Pfander, Boris ;

Jentsch, Stefan .

CELL, 2007, 129 (04) :665-679

[63] The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells [J].

Nag, A ;

Bondar, T ;

Shiv, S ;

Raychaudhuri, P .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (20) :6738-6747

[64] PSI-BLAST searches using hidden Markov models of structural repeats:: prediction of an unusual sliding DNA clamp and of β-propellers in UV-damaged DNA-binding protein [J].

Neuwald, AF ;

Poleksic, A .

NUCLEIC ACIDS RESEARCH, 2000, 28 (18) :3570-3580

[65] Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis [J].

Nishitani, H ;

Sugimoto, N ;

Roukos, V ;

Nakanishi, Y ;

Saijo, M ;

Obuse, C ;

Tsurimoto, T ;

Nakayama, KI ;

Nakayama, K ;

Fujita, M ;

Lygerou, Z ;

Nishimoto, T .

EMBO JOURNAL, 2006, 25 (05) :1126-1136

[66] CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation [J].

Nishitani, Hideo ;

Shiomi, Yasushi ;

Iida, Hiroka ;

Michishita, Masato ;

Takami, Toshihiro ;

Tsurimoto, Toshiki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (43) :29045-29052

[67] Ubiquitin proteasome system (UPS): what can chromatin do for you? [J].

O'Connell, Brenda C. ;

Harper, J. Wade .

CURRENT OPINION IN CELL BIOLOGY, 2007, 19 (02) :206-214

[68] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase [J].

Ohtake, Fumiaki ;

Baba, Atsushi ;

Takada, Ichiro ;

Okada, Maiko ;

Iwasaki, Kei ;

Miki, Hiromi ;

Takahashi, Sayuri ;

Kouzmenko, Alexander ;

Nohara, Keiko ;

Chiba, Tomoki ;

Fujii-Kuriyama, Yoshiaki ;

Kato, Shigeaki .

NATURE, 2007, 446 (7135) :562-566

[69] Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast [J].

Osaka, F ;

Saeki, M ;

Katayama, S ;

Aida, N ;

Toh-e, A ;

Kominami, K ;

Toda, T ;

Suzuki, T ;

Chiba, T ;

Tanaka, K ;

Kato, S .

EMBO JOURNAL, 2000, 19 (13) :3475-3484

[70] Mechanisms underlying ubiquitination [J].

Pickart, CM .

ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 :503-533

← 1 2 3 4 5 6 7 8 9 10 →