The role of anti-core antibody response in the detection of occult hepatitis B virus infection

被引：74

作者：

Urbani, Simona ^{[1
]}

Fagnoni, Francesco ^{[1
]}

Missale, Gabriele ^{[2
]}

Franchini, Massimo ^{[1
]}

机构：

[1] Univ Parma, Azienda Osped, Unita Operat Immunoematol & Med Trasfus, I-43123 Parma, Italy

[2] Univ Parma, Azienda Osped, Unita Operat Malattie Infett & Epatol, I-43123 Parma, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2010年 / 48卷 / 01期

关键词：

anti-core antibody response; HBV core (HBc); hepatitis B virus (HBV); occult hepatitis B infection; reactivation; transfusion; transplantation; IMMUNE-RESPONSE; HEPATOCELLULAR-CARCINOMA; BLOOD-DONORS; VIRAL-HEPATITIS; NATURAL-HISTORY; CLINICAL IMPACT; POSITIVE DONORS; SURFACE-ANTIGEN; HBV; TRANSMISSION;

D O I：

10.1515/CCLM.2010.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA in serum and/or in the liver of patients negative for hepatitis B surface antigen (HBsAg). Occult infection may impact in several different clinical contexts including the risk of HBV transmission with transfusion or transplantation, and endogenous viral reactivation. The gold standard test for detection of occult infection is the amplification of HBV DNA. However, the serological assay for the long-lasting antibody response to the highly immunogenic HBV core antigen (anti-HBc) represents a qualified candidate as a surrogate for DNA amplification, or for increasing overall sensitivity when assessing the risk of occult hepatitis in peripheral blood. The risk of occult hepatitis associated with anti-HBc seropositivity has been demonstrated extensively, and the presence of antibody response to HBc can be considered a sentinel marker of occult HBV infection. Clin Chem Lab Med 2010; 48: 23-9.

引用

页码：23 / 29

页数：7

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