Transmission networks of HIV-1 among men having sex with men in the Netherlands

被引：80

作者：

Bezemer, Daniela ^{[1
]}

van Sighem, Ard

Lukashov, Vladimir V. ^{[2
]}

van der Hoek, Lia ^{[2
]}

Back, Nicole ^{[2
]}

Schuurman, Rob ^{[3
]}

Boucher, Charles A. B. ^{[3
,4
]}

Claas, Eric C. J. ^{[5
]}

Boerlijst, Maarten C. ^{[6
]}

Coutinho, Roel A. ^{[7
,8
]}

de Wolf, Frank ^{[9
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, HIV Monitoring Fdn, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Utrecht Hosp, Dept Virol, Utrecht, Netherlands

[4] Erasmus MC, Dept Virol, Rotterdam, Netherlands

[5] Leiden Univ, Dept Med Microbiol, Med Ctr, Leiden, Netherlands

[6] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands

[7] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1105 AZ Amsterdam, Netherlands

[8] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3720 BA Bilthoven, Netherlands

[9] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England

来源：

AIDS | 2010年 / 24卷 / 02期

关键词：

HIV-1; molecular epidemiology; primary infection; transmission network; transmitted drug resistance; HUMAN-IMMUNODEFICIENCY-VIRUS; DRUG-RESISTANCE MUTATIONS; ANTIRETROVIRAL THERAPY; TRANSMITTED HIV-1; INFECTION; INDIVIDUALS; PREVALENCE; RATES; STAGE; RISK;

D O I：

10.1097/QAD.0b013e328333ddee

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Objective: To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands. Design: A phylogenetic tree was constructed from polymerase sequences isolated from 2877 HIV-1 subtype B-infected patients monitored as part of the AIDS Therapy Evaluation in the Netherlands (ATHENA) nationwide observational cohort. Methods: For MSM with a known date of infection, the most similar sequences were selected as potential transmission pairs when they clustered with bootstrap value of at least 99%. Time from infection to onward transmission was estimated as the Median time between dates of infection for each transmission pair. The source of infections with a resistant strain was traced using the entire phylogenetic tree. Results: Of sequences from 403 MSM with a known date of infection between 1987 and 2007, 175 (43%) formed 63 clusters. Median time to onward transmission was 1.4 years (interquartile range 0.6-2.7). Twenty-four (6%) MSM carried a virus with resistance-related mutations, 13 of these were in eight clusters together with sequences from 28 other patients in the entire phylogenetic tree. Six clusters contained sequences obtained from 29 men all presenting the same resistance-related mutations. Conclusion: From our selection of likely transmission pairs, we conclude that onward transmission of HIV-1 from infected MSM in the Netherlands happens both during and after primary infection. Transmission of resistant strains from the antiretroviral therapy-treated population is limited, but strains with resistance-related mutations have formed subepidemics. (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins

引用

页码：271 / 282

页数：12

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