Copper-Catalyzed Cross-Coupling of Alkyl and Aryl Grignard Reagents with Alkynyl Halides

被引：96

作者：

Cahiez, Gerard ^{[1
]}

Gager, Olivier ^{[1
]}

Buendia, Julien ^{[1
]}

机构：

[1] Univ Paris 13, Dept Chem FRE 3043, CNRS, F-93017 Bobigny, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 07期

关键词：

alkynes; copper; cross-coupling; Grignard reagents; VINYL ORGANOCOPPER COMPOUNDS; STEREOSPECIFIC SYNTHESIS; DERIVATIVES; BROMIDES; ACIDS; CARBONATION; 1-ALKYNES; IODIDES;

D O I：

10.1002/anie.200905816

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Good old copperl A new general procedure to couple aliphatic and aromatic Grignard reagents with alkynyl halides under copper catalysis is described (see scheme; NMP=N-methylpyrrolidinone). The reaction is chemoselective and allows preparation of a vast array of simple and functionalized internal alkynes in high yields. © 2010 Wiley-VCH Verlag GmbH &. Co. KCaA.

引用

页码：1278 / 1281

页数：4

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