Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342

被引：21

作者：

Fukuda, Takashi

Hasegawa, Yoko

Hagimori, Keiichi

Yamaguchi, Yuichi

Masuma, Rokuro

Tomoda, Hiroshi

Omura, Satoshi

机构：

[1] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

[3] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[4] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2006年 / 59卷 / 08期

关键词：

tensidol; miconazole potentiator; Aspergillus niger; furopyrrol; fungal metabolite; Candida albicans;

D O I：

10.1038/ja.2006.67

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new furopyrrols, designated tensidols A and B, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated and shown to have the common skeleton of 6-benzyl-6H-furo[2,3-b]pyrrole. Tensidols A and B potentiated miconazole activity against Candida albicans. Tensidols also showed moderate antimicrobial activity only against Pyricularia oryzae.

引用

页码：480 / 485

页数：6

共 7 条

[1] Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076 [J].