Mortalin: present and prospective

被引：75

作者：

Kaul, SC

Taira, K

Pereira-Smith, OM

Wadhwa, R

机构：

[1] Natl Inst Adv Ind Sci & Technol, Gene Funct Res Lab, AIST, Tsukuba, Ibaraki 3058566, Japan

[2] Natl Inst Adv Ind Sci & Technol, AIST, Gene Funct Res Lab, Tsukuba, Ibaraki 3058562, Japan

[3] Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78245 USA

[4] Chugai Res Inst Med Sci, Ibaraki 3004101, Japan

来源：

EXPERIMENTAL GERONTOLOGY | 2002年 / 37卷 / 10-11期

关键词：

mortalin; mthsp70; localization; proliferation;

D O I：

10.1016/S0531-5565(02)00135-3

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mortalin, also known as mthsp70/PBP74/GRP75, resides in multiple subcellular sites including mitochondria, ER, plasma membrane, cytoplasmic vesicles and cytosol. It is differentially distributed in normal and cancerous cells; the latter, when reverted back to normal phenotype, also show change in mortalin staining pattern similar to normal cells. Depending on its different subcellular niche and binding partner therein, mortalin is expected to perform multiple functions relevant to cell survival, control of proliferation and stress response. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1157 / 1164

页数：8

共 66 条

[11] PBP74, A NEW MEMBER OF THE MAMMALIAN 70-KDA HEAT-SHOCK PROTEIN FAMILY, IS A MITOCHONDRIAL PROTEIN [J].