ICAM-1 in acute myocardial infarction: A potential therapeutic target

被引：29

作者：

Benson, Victoria

McMahon, Aisling Clare

Lowe, Harry Claude

机构：

[1] Concord Repatriat Gen Hosp, Vasc Biol Lab, ANZAC, Med Res Inst, Concord, NSW 2139, Australia

[2] Concord Repatriat Gen Hosp, Dept Cardiol, Concord, NSW 2139, Australia

来源：

CURRENT MOLECULAR MEDICINE | 2007年 / 7卷 / 02期

关键词：

acute myocardial infarction; ischaemia reperfusion; adhesion molecule;

D O I：

10.2174/156652407780059131

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Current treatments for AMI centre on prompt restoration of epicardial coronary blood flow. Despite improvements, AMI is still associated with significant morbidity and mortality. Novel approaches are therefore keenly sought. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. It is implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow, both viewed as important to the pathophysiologic responses in AMI. ICAM-1 would therefore appear an important potential therapeutic target in this context, and is the subject of this review.

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收藏

页码：219 / 227

页数：9

相关论文

共 80 条

[1] ADHESION MOLECULES AND INFLAMMATORY INJURY [J].

ALBELDA, SM ;

SMITH, CW ;

WARD, PA .

FASEB JOURNAL, 1994, 8 (08) :504-512

[2] IRFI 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factor-κB and reduces the inflammatory response in myocardial ischaemia-reperfusion injury [J].

Altavilla, D ;

Deodato, B ;

Campo, GM ;

Arlotta, M ;

Miano, M ;

Squadrito, G ;

Saitta, A ;

Cucinotta, D ;

Ceccarelli, S ;

Ferlito, M ;

Tringali, M ;

Minutoli, L ;

Caputi, AP ;

Squadrito, F .

CARDIOVASCULAR RESEARCH, 2000, 47 (03) :515-528

[3]

[Anonymous], 2005, HEART DIS STROKE STA

[4] PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated IκBα degradation [J].

Bao, JL ;

Sato, K ;

Li, M ;

Gao, YH ;

Abid, R ;

Aird, W ;

Simons, M ;

Post, MJ .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (06) :H2612-H2618

[5] Double-blind, randomized trial of an Anti-CD18 antibody in conjunction with recombinant tissue plasminogen activator for acute myocardial infarction - Limitation of myocardial infarction following thrombolysis in acute myocardial infarction (LIMIT AMI) study [J].

Baran, KW ;

Nguyen, M ;

McKendall, GR ;

Lambrew, CT ;

Dykstra, G ;

Palmeri, ST ;

Gibbons, RJ ;

Borzak, S ;

Sobel, BE ;

Gourlay, SG ;

Rundle, AC ;

Gibson, CM ;

Barron, HV .

CIRCULATION, 2001, 104 (23) :2778-2783

[6] Cytosolic phospholipase A2-Mediated ICAM-1 expression is calcium dependent [J].

Barnett, CC ;

Moore, EE ;

Silliman, CC ;

Abdalla, EK ;

Partrick, DA ;

Curley, SA .

JOURNAL OF SURGICAL RESEARCH, 2001, 99 (02) :307-310

[7] The neutrophil as a mediator of myocardial ischemia-reperfusion injury: time to move on [J].

Baxter, GF .

BASIC RESEARCH IN CARDIOLOGY, 2002, 97 (04) :268-275

[8] DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats [J].

Bhindi, R. ;

Khachigian, L. M. ;

Lowe, H. C. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2006, 4 (07) :1479-1483

[9] Rat models of myocardial infarction - Pathogenetic insights and clinical relevance [J].

Bhindi, Ravinay ;

Whiting, Paul K. ;

McMahon, Aisling C. ;

Khachigian, Levon M. ;

Lowe, Harry C. .

THROMBOSIS AND HAEMOSTASIS, 2006, 96 (05) :602-610

[10] Lactosylceramide mediates tumor necrosis factor-α-induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells [J].

Bhunia, AK ;

Arai, T ;

Bulkley, G ;

Chatterjee, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (51) :34349-34357

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