MicroRNAs and genomic instability

被引:70
作者
Huppi, Konrad
Volfovsky, Natalia
Mackiewicz, Mark
Runfola, Timothy
Jones, Tamara L.
Martin, Scott E.
Stephens, Robert
Caplen, Natasha J.
机构
[1] NCI, Gene Silencing Sect, Genet Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA
[2] SAIC Frederick Inc, NCI, Adv Biomed Comp Ctr, NIH, Frederick, MD USA
关键词
microRNAs; genomic instability; mouse genome; integration sites;
D O I
10.1016/j.semcancer.2006.10.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A new species of non-coding RNA, microRNAs (miRNAs) has been identified that may regulate the expression of as many as one third to one half of all protein encoding genes. MicroRNAs are found throughout mammalian genomes, but an association between the location of these miRNAs and regions of genomic instability (or fragile sites) in humans has been suggested [1]. In this review we discuss the possible role of altered miRNA expression on human cancer and conduct an analysis correlating the physical location of murine miRNAs with sites of genetic alteration in mouse models of cancer. Published by Elsevier Ltd.
引用
收藏
页码:65 / 73
页数:9
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