MicroRNAs and genomic instability

被引：70

作者：

Huppi, Konrad

Volfovsky, Natalia

Mackiewicz, Mark

Runfola, Timothy

Jones, Tamara L.

Martin, Scott E.

Stephens, Robert

Caplen, Natasha J.

机构：

[1] NCI, Gene Silencing Sect, Genet Branch, Ctr Canc Res,NIH, Bethesda, MD 20892 USA

[2] SAIC Frederick Inc, NCI, Adv Biomed Comp Ctr, NIH, Frederick, MD USA

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 01期

关键词：

microRNAs; genomic instability; mouse genome; integration sites;

D O I：

10.1016/j.semcancer.2006.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new species of non-coding RNA, microRNAs (miRNAs) has been identified that may regulate the expression of as many as one third to one half of all protein encoding genes. MicroRNAs are found throughout mammalian genomes, but an association between the location of these miRNAs and regions of genomic instability (or fragile sites) in humans has been suggested [1]. In this review we discuss the possible role of altered miRNA expression on human cancer and conduct an analysis correlating the physical location of murine miRNAs with sites of genetic alteration in mouse models of cancer. Published by Elsevier Ltd.

引用

收藏

页码：65 / 73

页数：9

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