Using in situ Raman monitoring as a tool for rapid optimisation and scale-up of microwave-promoted organic synthesis:: esterification as an example

被引：25

作者：

Leadbeater, Nicholas E.

Smith, Rebecca J.

Barnard, T. Michael

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

[2] CEM Microwave Technol, Matthews, NC 28106 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 05期

关键词：

D O I：

10.1039/b615597a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave-promoted esterification reactions have been monitored using in situ Raman spectroscopy. Having optimised a reaction on a 23 mmol scale, it was transferred to a larger reaction vessel and scaled up to 0.26 mol, again with Raman monitoring. With conditions in hand, an automated stop-flow apparatus was used to prepare 5.7 moles of product.

引用

页码：822 / 825

页数：4

共 34 条

[11] Enzymatic esterification between n-alcohol homologs and n-caprylic acid in non-aqueous medium under microwave irradiation [J].