Real-time monitoring of microwave-promoted Suzuki coupling reactions using in situ Raman spectroscopy

被引：36

作者：

Leadbeater, Nicholas E. ^{[1
]}

Smith, Rebecca J. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 20期

关键词：

D O I：

10.1021/ol061803f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The progress of microwave-promoted Suzuki reactions has been monitored using an in situ Raman spectroscopy apparatus assembled from commercially available components. It was possible to see if any reaction occurred and, if so, when it reached completion. In addition, the monitoring technique has given us an insight into the reaction, confirming that, when run in aqueous media, the coupling is in competition with the rapid deboronation of the boronic acid.

引用

页码：4588 / 4591

页数：3

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