RNAdb 2.0-an expanded database of mammalian non-coding RNAs

被引:125
作者
Pang, Ken C.
Stephen, Stuart
Dinger, Marcel E.
Engstrom, Par G.
Lenhard, Boris
Mattick, John S. [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, ARC Special Res Ctr Funct & Appl Genom, Brisbane, Qld 4072, Australia
[2] Austin Hosp, Melbourne Ctr Clin Sci, Ludwig Inst Canc Res, T Cell Lab, Melbourne, Vic 3084, Australia
[3] Univ Bergen, Bergen Ctr Computat Sci, Computat Biol Unit, N-5020 Bergen, Norway
[4] Karolinska Inst, Dept Cell & Mol Biol, Program Genom & Bioinformat, Stockholm, Sweden
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
D O I
10.1093/nar/gkl926
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RNAdb is a comprehensive database of mammalian non-protein-coding RNAs (ncRNAs). There is increasing recognition that ncRNAs play important regulatory roles in multicellular organisms, and there is an expanding rate of discovery of novel ncRNAs as well as an increasing allocation of function. In this update to RNAdb, we provide nucleotide sequences and annotations for tens of thousands of non-housekeeping ncRNAs, including a wide range of mammalian microRNAs, small nucleolar RNAs and larger mRNA-like ncRNAs. Some of these have documented functions and/or expression patterns, but the majority remain of unclear significance, and include PIWI-interacting RNAs, ncRNAs identified from the latest rounds of large-scale cDNA sequencing projects, putative antisense transcripts, as well as ncRNAs predicted on the basis of structural features and alignments. Improvements to the database comprise not only new and updated ncRNA datasets, but also provision of microarray-based expression data and closer interface with more specialized ncRNA resources such as miRBase and snoRNA-LBME-db.
引用
收藏
页码:D178 / D182
页数:5
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