A Molecular Link between AKT Regulation and Chemotherapeutic Response

被引：26

作者：

Dibble, Christian C. ^{[1
]}

Manning, Brendan D. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

CANCER CELL | 2009年 / 16卷 / 03期

关键词：

CANCER;

D O I：

10.1016/j.ccr.2009.08.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The protein kinase AKT is frequently activated in human cancers and has been implicated in resistance to chemotherapy. In this issue of Cancer Cell, Pei et al. show that FKBP51 negatively regulates AKT through the phosphatase PHLPP. This regulation appears to be a determinant of chemosensitivity in cancer cells.

引用

页码：178 / 180

页数：3

共 9 条

[1] PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms [J].

Brognard, John ;

Sierecki, Emma ;

Gao, Tianyan ;

Newton, Alexandra C. .

MOLECULAR CELL, 2007, 25 (06) :917-931

[2] Defining the role of mTOR in cancer [J].

Guertin, David A. ;

Sabatini, David M. .

CANCER CELL, 2007, 12 (01) :9-22

[3] Akt/PKB signaling mechanisms in cancer and chemoresistance [J].

Kim, D ;

Dan, HC ;

Park, S ;

Yang, L ;

Liu, QY ;

Kaneko, S ;

Ning, JY ;

He, LL ;

Yang, H ;

Sun, M ;

Nicosia, SV ;

Cheng, JQ .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2005, 10 :975-987

[4] Gemcitabine and cytosine arabinoside cytotoxicity: Association with lymphoblastoid cell expression [J].

Li, Liang ;

Fridley, Brooke ;

Kalari, Krishna ;

Jenkins, Gregory ;

Batzler, Anthony ;

Safgren, Stephanie ;

Hildebrandt, Michelle ;

Ames, Matthew ;

Schaid, Daniel ;

Wang, Liewei .

CANCER RESEARCH, 2008, 68 (17) :7050-7058

[5] AKT/PKB signaling: Navigating downstream [J].

Manning, Brendan D. ;

Cantley, Lewis C. .

CELL, 2007, 129 (07) :1261-1274

[6] PDK1, the master regulator of AGC kinase signal transduction [J].

Mora, A ;

Komander, D ;

van Aalten, DMF ;

Alessi, DR .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (02) :161-170

[7] FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt [J].

Pei, Huadong ;

Li, Liang ;

Fridley, Brooke L. ;

Jenkins, Gregory D. ;

Kalari, Krishna R. ;

Lingle, Wilma ;

Petersen, Gloria ;

Lou, Zhenkun ;

Wang, Liewei .

CANCER CELL, 2009, 16 (03) :259-266

[8] Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy [J].

Wendel, HG ;

de Stanchina, E ;

Fridman, JS ;

Malina, A ;

Ray, S ;

Kogan, S ;

Cordon-Cardo, C ;

Pelletier, J ;

Lowe, SW .

NATURE, 2004, 428 (6980) :332-337

[9] Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP [J].

Yang, J ;

Cron, P ;

Good, VM ;

Thompson, V ;

Hemmings, BA ;

Barford, D .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (12) :940-944

← 1 →