Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines

被引：22

作者：

Bertucci, Anthony ^{[2
]}

Zoccola, Didier ^{[2
]}

Tambutte, Sylvie ^{[2
]}

Vullo, Daniela ^{[1
]}

Supuran, Claudiu T. ^{[1
]}

机构：

[1] Univ Florence, Dipartimento Chim 2, I-50019 Florence, Italy

[2] Ctr Sci Monaco, MC-98000 Principality Of Monaco, Monaco

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 06期

关键词：

THERAPEUTIC APPLICATIONS; ISOZYME-II; CALCIFICATION; PHOTOSYNTHESIS; MECHANISMS; INHIBITORS; ENZYME; LOCALIZATION; EXPRESSION; MEMORY;

D O I：

10.1016/j.bmc.2010.01.059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on k(cat) and have been separated in weak (K-A in the range of 21-126 mu M), medium (10.1-19 mu M) and strong enzyme activators (K-A of 0.18-3.21 mu M). D-DOPA was found to be the best coral enzyme activator, with an activation constant K-A of 0.18 mu M. This enhancement of STPCA activity, as well as previous enzyme inhibition results, might now be tested on living organisms to better understand the role played by these enzymes in the coral calcification processes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2300 / 2303

页数：4

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