Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

被引：17

作者：

Boger, DL

Labroli, MA

Marsilje, TH

Jin, Q

Hedrick, MP

Baker, SJ

Shim, JH

Benkovic, SJ

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0968-0896(00)00051-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and evaluation of a series of conformationally restricted analogues of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

引用

收藏

页码：1075 / 1086

页数：12

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