Integrated Broadband Microwave and Microfluidic Sensor Dedicated to Bioengineering

被引:226
作者
Grenier, Katia [1 ]
Dubuc, David [1 ]
Poleni, Paul-Emile [2 ]
Kumemura, Momoko [2 ]
Toshiyoshi, Hiroshi [2 ]
Fujii, Teruo [2 ]
Fujita, Hiroyuki [2 ]
机构
[1] Univ Tokyo, Lab Integrated Micromech Syst, Natl Ctr Sci Res, LIMMS,CNRS, Tokyo 1138656, Japan
[2] Univ Tokyo, Ctr Int Res Micromechatron CIRMM, IIS, Tokyo 1538505, Japan
基金
日本学术振兴会;
关键词
Biology; biomedical transducers; coplanar waveguides; fluidics; microwave spectroscopy; permittivity; PERMITTIVITY MEASUREMENTS; INHIBITION; LIQUIDS; CANCER; WATER; GHZ;
D O I
10.1109/TMTT.2009.2034226
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper presents an innovative high-frequency-based biosensor, which combines both microwave detection and microfluidic network for time-efficient and accurate biological analysis. It is composed of a coplanar waveguide with a microfluidic channel placed on top. With the help of an appropriate de-embedding technique and modeling of the measurements, the relative effective permittivity of human umbilical vein endothelial cells has been evaluated successfully. Furthermore, experiments have been performed with the sensor on various cell concentrations in suspension, which validates its use in bioengineering applications such as cell quantification and counting in solution. This sensor requires no direct contact or use of labels on the cells, contrary to other usual types of biosensors (optical, mechanical or dc/low-frequency-detection-based ones).
引用
收藏
页码:3246 / 3253
页数:8
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