New analogs of the pyripyropene family of ACAT inhibitors via alpha-pyrone fragmentation and gamma-acylation/cyclization

被引：31

作者：

Obata, R

Sunazuka, T

Tian, ZM

Tomoda, H

Harigaya, Y

Omura, S

Smith, AB

机构：

[1] KITASATO INST, BIOL FUNCT RES CTR, MINATO KU, TOKYO 108, JAPAN

[2] UNIV PENN, RES STRUCT MATTER LAB, PHILADELPHIA, PA 19104 USA

[3] KITASATO UNIV, SCH PHARMACEUT SCI, MINATO KU, TOKYO 108, JAPAN

[4] UNIV PENN, DEPT CHEM, MONELL CHEM SENSES CTR, PHILADELPHIA, PA 19104 USA

来源：

CHEMISTRY LETTERS | 1997年 / 09期

关键词：

D O I：

10.1246/cl.1997.935

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pyridine moiety of pyripyropene A was replaced with other aromatic and heteroaromatic substituents via alpha-pyrone degradation followed by dienolate gamma-acylation and in site cyclization.

引用

页码：935 / 936

页数：2

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