Playing for half the deck: the molecular biology of meiosis

被引:40
作者
Champion, MD [1 ]
Hawley, RS [1 ]
机构
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
关键词
D O I
10.1038/ncb-nm-fertilityS50
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Meiosis reduces the number of chromosomes carried by a diploid organism by half, partitioning precisely one haploid genome into each gamete. The basic events of meiosis reflect three meiosis-specific processes: first, pairing and synapsis of homologous chromosomes; second, high-frequency, precisely controlled, reciprocal crossover; third, the regulation of sister-chromatid cohesion (SCC), such that during anaphase 1, SCC is released along the chromosome arms, but not at the centromeres. The failure of any of these processes can result in aneuploidy or a failure of meiotic segregation.
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页码:S50 / S56
页数:7
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