Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats

被引：8

作者：

Beaty, Shannon M. ^{[1
]}

Nachbagauer, Raffael ^{[1
]}

Hirsh, Ariana ^{[1
]}

Vigant, Frederic ^{[1
]}

Duehr, James ^{[1
]}

Azarm, Kristopher D. ^{[1
]}

Stelfox, Alice J. ^{[3
]}

Bowden, Thomas A. ^{[3
]}

Duprex, W. Paul ^{[2
]}

Krammer, Florian ^{[1
]}

Lee, Benhur ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, 1 Gustave L Levy Pl,1124, New York, NY 10029 USA

[2] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02215 USA

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Div Struct Biol, Oxford OX1 2JD, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 02期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

neutralizing antibodies; mumps virus; viral envelope proteins; zoonoses; cross-reactive antibodies;

D O I：

10.1093/infdis/jiw534

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuV(JL5)), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuV(JL5)). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuV(JL5)-F/HNBMV) virus and rMuV(JL5) were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuV(JL5) infection had cross-neutralizing activity against rMuV(JL5)-F/HNBMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.

引用

页码：209 / 213

页数：5

共 14 条

[1] Mumps Outbreaks in Vaccinated Populations: Are Available Mumps Vaccines Effective Enough to Prevent Outbreaks? [J].

Dayan, Gustavo H. ;

Rubin, Steven .

CLINICAL INFECTIOUS DISEASES, 2008, 47 (11) :1458-1467

[2] Bats host major mammalian paramyxoviruses [J].

Drexler, Jan Felix ;

Corman, Victor Max ;

Mueller, Marcel Alexander ;

Maganga, Gael Darren ;

Vallo, Peter ;

Binger, Tabea ;

Gloza-Rausch, Florian ;

Rasche, Andrea ;

Yordanov, Stoian ;

Seebens, Antje ;

Oppong, Samuel ;

Sarkodie, Yaw Adu ;

Pongombo, Celestin ;

Lukashev, Alexander N. ;

Schmidt-Chanasit, Jonas ;

Stoecker, Andreas ;

Borges Carneiro, Aroldo Jose ;

Erbar, Stephanie ;

Maisner, Andrea ;

Fronhoffs, Florian ;

Buettner, Reinhard ;

Kalko, Elisabeth K. V. ;

Kruppa, Thomas ;

Franke, Carlos Roberto ;

Kallies, Rene ;

Yandoko, Emmanuel R. N. ;

Herrler, Georg ;

Reusken, Chantal ;

Hassanin, Alexandre ;

Krueger, Detlev H. ;

Matthee, Sonja ;

Ulrich, Rainer G. ;

Leroy, Eric M. ;

Drosten, Christian .

NATURE COMMUNICATIONS, 2012, 3

[3]

Galazka AM, 1999, B WORLD HEALTH ORGAN, V66, P509, DOI DOI 10.1007/BF02727158

[4] Mumps [J].

Hviid, Anders ;

Rubin, Steven ;

Muehlemann, Kathrin .

LANCET, 2008, 371 (9616) :932-944

[5] Cross-Neutralization between Human and African Bat Mumps Viruses [J].

Katoh, Hiroshi ;

Kubota, Toru ;

Ihara, Toshiaki ;

Maeda, Ken ;

Takeda, Makoto ;

Kidokoro, Minoru .

EMERGING INFECTIOUS DISEASES, 2016, 22 (04) :703-706

[6] A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates [J].

Krammer, Florian ;

Margine, Irina ;

Tan, Gene S. ;

Pica, Natalie ;

Krause, Jens C. ;

Palese, Peter .

PLOS ONE, 2012, 7 (08)

[7] Functional Properties and Genetic Relatedness of the Fusion and Hemagglutinin-Neuraminidase Proteins of a Mumps Virus-Like Bat Virus [J].

Krueger, Nadine ;

Hoffmann, Markus ;

Drexler, Jan Felix ;

Mueller, Marcel Alexander ;

Corman, Victor Max ;

Sauder, Christian ;

Rubin, Steven ;

He, Biao ;

Orvell, Claes ;

Drosten, Christian ;

Herrler, Georg .

JOURNAL OF VIROLOGY, 2015, 89 (08) :4539-4548

[8] The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat [J].

Kühnel, K ;

Jarchau, T ;

Wolf, E ;

Schlichting, I ;

Walter, U ;

Wittinghofer, A ;

Strelkov, SV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17027-17032

[9] Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System [J].

Margine, Irina ;

Palese, Peter ;

Krammer, Florian .

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2013, (81) :e51112

[10] The molecular epidemiology of mumps virus [J].

Muehlemann, Kathrin .

INFECTION GENETICS AND EVOLUTION, 2004, 4 (03) :215-219

← 1 2 →