Polyaza[n]paracyclophanes as synthetic models of Zn containing enzymes. The role of a non coordinated nitrogen atom in the proximity of the metal

被引：33

作者：

Altava, B

Burguete, MI

Luis, SV

Miravet, JF

GarciaEspana, E

Marcelino, V

Soriano, C

机构：

[1] ESTEC, DEPT ORGAN & INORGAN CHEM, CASTELLO DE LA PLANA 12080, SPAIN

[2] UNIV VALENCIA, DEPT INORGAN & ORGAN CHEM, E-46100 BURJASSOT, SPAIN

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(97)00144-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,6,9,13-Tetraaza[14]paracyclophane (3, B323) represents a simple model for Zn containing enzymes like HCAII which possess additional reactive groups in the proximity of the metal center. The Zn2+.3 complex shows notable catalytic activity for the hydrolysis of p-nitrophenyl acetate. Structural modifications of 3 which affect to the non coordinated nitrogen atom greatly modify the catalytic activity of the receptor. (C) 1997 Elsevier Science Ltd.

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页码：4751 / 4762

页数：12

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