Low pH does not modulate antioxidant status of diphenyl ditelluride but exacerbates Fe (II)-induced lipid peroxidation in liver preparation

被引：6

作者：

Hassan, Waseem ^{[1
]}

Ibrahim, Mohammad ^{[1
]}

Rocha, Joao B. T. ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, Ctr Ciencias Nat & Exatas, BR-97105900 Santa Maria, RS, Brazil

来源：

DRUG AND CHEMICAL TOXICOLOGY | 2009年 / 32卷 / 04期

关键词：

pH; Lipid peroxidation; diphenyl ditelluride; DELTA-AMINOLEVULINATE DEHYDRATASE; IN-VITRO; ORGANOTELLURIUM COMPOUNDS; CYTOSKELETAL PROTEINS; COMPOUNDS PREVENT; CEREBRAL-CORTEX; IRON; DISELENIDE; ORGANOSELENIUM; INHIBITORS;

D O I：

10.1080/01480540903127332

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The relationship of acidosis and lipid peroxidation in liver homogenate was studied and the effect of pH on the antioxidant potential of diphenyl ditelluride is reported. Low pH increased the rate of lipid peroxidation both in the absence and presence of Fe (II), while diphenyl ditelluride (DPDT) inhibited the rate of lipid peroxidation in a concentration-dependent manner at all studied pH values. However, the change in pH did not alter the antioxidant activity of the compound. This study shows acidosis catalyzed oxidative stress in liver homogenate and the antioxidant potential of diphenyl ditelluride.

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收藏

页码：438 / 442

页数：5

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