Organocatalytic asymmetric hydrophosphination of nitroalkenes

被引:95
作者
Bartoli, Giuseppe [1 ]
Bosco, Marcella [1 ]
Carlone, Armando [1 ]
Locatelli, Manuela [1 ]
Mazzanti, Andrea [1 ]
Sambri, Letizia [1 ]
Melchiorre, Paolo [1 ]
机构
[1] Univ Bologna, Dipartimento Chim Organ A Mangini, Alma Mater Studiorum, I-40136 Bologna, Italy
关键词
D O I
10.1039/b613477g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The use of a bifunctional Cinchona alkaloid catalyst has provided a new organocatalytic strategy for the enantioselective addition of diphenylphosphine to a range of nitroalkenes, affording optically active beta-nitrophosphines (up to 99% ee after crystallization); this organocatalytic approach, providing a direct route to a new class of potentially useful enantiopure P,N-ligands, constitutes a bridge between the two complementary areas of asymmetric catalysis: organo- and metal-catalyzed transformations.
引用
收藏
页码:722 / 724
页数:3
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