Analytical strategies in metabonomics

被引：425

作者：

Lenz, Eva Maria ^{[1
]}

Wilson, Ian D. ^{[1
]}

机构：

[1] AstraZeneca, Dept Drug Metab & Pharmacokinet, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 02期

关键词：

global metabolite profiling; metabotyping; metabonomics; metabolomics; spectroscopic analysis; separations; hyphenation;

D O I：

10.1021/pr0605217

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To perform metabonomics investigations, it is necessary to generate comprehensive metabolite profiles for complex samples such as biofluids and tissue/tissue extracts. Analytical technologies that can be used to achieve this aim are constantly evolving, and new developments are changing the way in which such profiles' metabolite profiles can be generated. Here, the utility of various analytical techniques for global metabolite profiling, such as, e.g., H-1 NMR, MS, HPLC-MS, and GC-MS, are explored and compared.

引用

页码：443 / 458

页数：16

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