Enhancing the surface sensitivity of colorimetric resonant optical biosensors

被引：73

作者：

Cunningham, B ^{[1
]}

Qiu, J ^{[1
]}

Li, P ^{[1
]}

Lin, B ^{[1
]}

机构：

[1] SRU Biosyst, Woburn, MA 01801 USA

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2002年 / 87卷 / 02期

关键词：

optical biosensor; proteomics; micro-replication; resonant filter; direct assay;

D O I：

10.1016/S0925-4005(02)00273-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Through alteration of the structure of a colorimetric resonant optical biosensor, the relative contribution of surface-binding effects to bulk refractive index effects can be influenced to favor detection of material in direct proximity to the sensor surface structure. The sequential buildup of polyelectrolyte monolayers has been used as a characterization method for determining the sensitivity of the device as a function of deposited thickness in an aqueous environment. A subtle change in the sensor structure is found to enhance surface sensitivity by similar to4.5 x. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：365 / 370

页数：6

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