Inhibition of bacterial RNA polymerases. Peptide metabolites from the cultures of Streptomyces sp.

被引：31

作者：

Miao, SC

Anstee, MR

LaMarco, K

Matthew, J

Huang, LHT

Brasseur, MM

机构：

[1] Tularik Inc., South San Francisco, CA 94080

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 08期

关键词：

D O I：

10.1021/np960709c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The fermentation culture of a soil strain of Streptomyces has been chemically investigated for its inhibitory activity against RNA polymerases from the bacteria Escherichia coli and Staphylococcus aureus. The active component was found to be the unusual bicyclodepsipeptide salinamide A (1) recently discovered from a marine Streptomycete. The same extract also yielded a new cyclohexapeptide natural product, desotamide (2), the structure elucidation of which was based on amino acid analysis, detailed spectroscopic data interpretation, and peptide synthesis.

引用

页码：858 / 861

页数：4

共 21 条

[1] A NOVEL 4-AMINOBENZYL ESTER-BASED CARBOXY-PROTECTING GROUP FOR SYNTHESIS OF ATYPICAL PEPTIDES BY FMOC-BU(T) SOLID-PHASE CHEMISTRY [J].