Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU)

被引：55

作者：

Marik, Jan ^{[1
]}

Sutcliffe, Julie L. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2007年 / 65卷 / 02期

关键词：

44-[F-18]fluorobenzoic acid; F-18]FBA; N-succinimidyl 4-[F-18]fluorobenzoate; F-18]SFB; positron emission tomography PET; chemistry process control unit (CPCU);

D O I：

10.1016/j.apradiso.2006.06.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

The widely used bifunctional labeling reagent 4-[F-18]fluorobenzoic acid ([F-18]FBA) and its activated form N-succinimidyl 4-[F-18]fluorobenzoate ([F-18]SFB) were prepared using a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [F-18]FDG module. The products were obtained with a radiochemical yield greater than 99% with decay corrected yields of 77 +/- 5% (n = 4) for [F-18]FBA and 46 +/- 5% (it = 4) for [F-18]SFB. The presented synthetic procedure is highly reproducible and fully automated. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：199 / 203

页数：5

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