Nickel-Catalyzed Reaction of Arylzinc Reagents with N-Aromatic Heterocycles: A Straightforward Approach to C-H Bond Arylation of Electron-Deficient Heteroaromatic Compounds

被引：258

作者：

Tobisu, Mamoru ^{[1
]}

Hyodo, Isao ^{[2
]}

Chatani, Naoto ^{[2
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Frontier Res Base Global Young Researchers, Fac Engn, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Appl Chem, Frontier Res Base Global Young Researchers, Fac Engn, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 34期

关键词：

SELECTIVE ALKENYLATION; COUPLING REACTION; PYRIDINES; HALIDES; SYSTEM; OXIDES;

D O I：

10.1021/ja9053509

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of electron-deficient N-heteroaromatic compounds, such as pyridines and quinolines, with arylzinc reagents in the presence of a catalytic amount of a nickel complex affords the arylated products. The reaction is likely to proceed through a format nucleophilic 1,2-addition, thus exhibiting a reactivity complementary to conventional direct arylation through electrophilic substitution.

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页码：12070 / +

页数：3

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