Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition

被引：165

作者：

Prasuhn, Duane E., Jr.

Yeh, Robert M.

Obenaus, Andre

Manchester, Marianne

Finn, M. G.

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA USA

[3] Loma Linda Univ, Non Invas Imaging Lab, Loma Linda, CA 92350 USA

[4] Scripps Res Inst, Dept Cell Biol, La Jolla, CA USA

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 12期

关键词：

D O I：

10.1039/b615084e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd3+ ions by coordination to the viral nucleoprotein show increased T-1 relaxivity relative to free Gd(DOTA) complexes in solution.

引用

页码：1269 / 1271

页数：3

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