Iron-Catalyzed Negishi Coupling Toward an Effective Olefin Synthesis

被引：76

作者：

Hatakeyama, Takuji ^{[1
]}

Nakagawa, Naohisa ^{[1
,2
]}

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, Int Res Ctr Elements Sci, Inst Chem Res, Kyoto 6110011, Japan

[2] Kyoto Univ, Dept Energy & Hydrocarbon Chem, Grad Sch Engn, Kyoto 6110011, Japan

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

关键词：

SECONDARY ALKYL-HALIDES; ARYL GRIGNARD-REAGENTS; CROSS-COUPLINGS; BROMIDES; LIGANDS; IODIDES; COBALT; ZINC;

D O I：

10.1021/ol901555r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A selective iron-catalyzed cross-coupling of alkyl halides with alkenylzinc reagents is described. Primary and secondary alkyl chlorides, bromides, and iodides take part in the reaction to give the corresponding olefins in good to excellent yields In a stereospecific manner. High functional group compatibility is also demonstrated by using combinations of substrates possessing rather reactive substituents.

引用

页码：4496 / 4499

页数：4

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