Poly(ortho esters) - their development and some recent applications

被引：58

作者：

Heller, J ^{[1
]}

Barr, J ^{[1
]}

Ng, SY ^{[1
]}

Shen, HR ^{[1
]}

Schwach-Abdellaoui, K ^{[1
]}

Emmahl, S ^{[1
]}

Rothen-Weinhold, A ^{[1
]}

Gurny, R ^{[1
]}

机构：

[1] Univ Geneva, Sch Pharm, Geneva, Switzerland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2000年 / 50卷 / 01期

关键词：

poly(ortho esters); developments; applications; polymerization;

D O I：

10.1016/S0939-6411(00)00085-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poly(ortho esters) have been under development since the early 1970s and four families of such polymers have been described. Of most interest are poly(ortho ester) III and poly(ortho ester) IV. Poly(ortho ester) IV is a semisolid material that has been shown to be highly biocompatible and is currently being investigated as an adjunct to glaucoma filtering surgery and other ocular applications. However, the polymerization is difficult to control and is not readily scaled up. Poly(ortho ester) IV can be easily prepared in a highly reproducible manner, is very stable provided moisture is rigorously excluded and has also been shown to be highly biocompatible. It is currently under development for a variety of applications, such as ocular delivery, protein release, post-operative pain treatment and post-operative cancer treatment. (C) 2000 Elsevier Science B.V. All rights reserved.

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页码：121 / 128

页数：8

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