Asymmetric synthesis of the key intermediate of an SP antagonist RPR107880 using a base-catalyzed Diels-Alder reaction

被引：44

作者：

Okamura, H ^{[1
]}

Shimizu, H ^{[1
]}

Nakamura, Y ^{[1
]}

Iwagawa, T ^{[1
]}

Nakatani, M ^{[1
]}

机构：

[1] Kagoshima Univ, Fac Sci, Dept Chem & Biosci, Kagoshima 8900065, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 21期

关键词：

base-catalyzed Diels-Alder reaction; asymmetric synthesis; RPR; 107880; substance P;

D O I：

10.1016/S0040-4039(00)00555-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of the key intermediate of RPR 107880, a substance P antagonist, using a base-catalyzed Diels-Alder reaction of 3-hydroxy-2-pyrone and N-benzylmaleimide is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4147 / 4150

页数：4

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