Synthesis of 3′-O2-(azaheterocycle)-thymidines

被引：5

作者：

Prestat, G

Dubreuil, D

Adjou, A

Pradère, JP

Lebreton, J

Evers, M

Henin, Y

机构：

[1] Fac Sci & Tech, Organ Synth Lab, CNRS, UMR 6513, F-44322 Nantes 3, France

[2] Fac Sci & Tech, Chim Organ Struct Lab, Abidjan, Cote Ivoire

[3] Rhone Poulenc Rorer, Ctr Rech Vitry Alfortville, F-94403 Vitry, France

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 04期

关键词：

3 '-modified thymidine; thioacylamidines; thioacylimines; 4H-1,3-thiazines; thiazoles; thiazol-2-ine; 1-thia-3-azabutadienes;

D O I：

10.1080/15257770008035021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 3'-O-2-(azaheterocycle)-thymidines is presented from 1-thia-3-aza-1,3-butadiene precursors (N-thioacylamidines). A variety of heterocycles is accessible using the dienic, the electrophilic or the nucleophilic reactivity of these thia-azabutadiene systems. 3'-O-2-(azaheterocycle)-thymidine analogues are regarded as potential substrates to interfere with the DNA-polymerization process.

引用

收藏

页码：735 / 748

页数：14

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